THE DOCKING STUDY OF THE INTERACTION BETWEEN FOOD SUPPLEMENTS AND BINIMETINIB

Abstract

The primary objective of this investigation is to uncover notable interactions between dietary supplements and the pharmaceutical agent Binimetinib with the CYP3A4 receptor, employing the HEX 8.0 docking program. Binding energy is utilized as a critical measure to assess the strength and stability of these interactions. Our analysis reveals a robust binding affinity between Binimetinib and CYP3A4. However, when associated with Naringin and Naringenin, an increase in binding energy is observed, indicating a slightly lower drug metabolism in the presence of these supplements. These findings underscore the critical importance of understanding food-drug interactions and the potential alterations in systemic bioavailability and drug pharmacokinetics that may result. Interactions with CYP3A4 significantly affect treatment efficacy and safety. Dietary habits and supplement intake can influence these interactions. Therefore, a thorough understanding and vigilant monitoring of these dynamics are imperative to ensure the appropriateness and safety of therapeutic regimens.