Affiliation:
1. Cancer Research UKCambridge Institute, University of Cambridge, Cambridge, UK
Abstract
Most breast cancers are driven by a transcription factor called oestrogen receptor (ER). Understanding the mechanisms of ER activity in breast cancer has been a major research interest and recent genomic advances have revealed extraordinary insights into how ER mediates gene transcription and what occurs during endocrine resistance. This review discusses our current understanding on ER activity, with an emphasis on several evolving, but important areas of ER biology.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
74 articles.
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