Tamoxifen: a most unlikely pioneering medicine
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd1031.pdf
Reference96 articles.
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3. Harper, M. J. & Walpole, A. L. A new derivative of triphenylethylene: effect on implantation and mode of action in rats. J. Reprod. Fertil. 13, 101–119 (1967). First detailed report of the antifertility activity of tamoxifen in rats. The anti-oestrogen lowered circulating cholesterol but did not increase desmosterol.
4. Harper, M. J. & Walpole, A. L. Mode of action of I. C. I. 46,474 in preventing implantation in rats. J. Endocrinol. 37, 83–92 (1967).
5. Cole, M. P., Jones, C. T. & Todd, I. D. A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474. Br. J. Cancer 25, 270–275 (1971). Reports the first clinical study to show tamoxifen had equivalent efficacy to historical results of standard endocrine therapy, but with fewer side effects.
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