DIE AUSSCHEIDUNG VON PORTER-SILBER-AKTIVEN 11-DESOXYCORTICOSTEROIDEN BEI GESUNDEN FRAUEN SOWIE AM ENDE DER SCHWANGERSCHAFT UND BEI INTRAUTERINEM FRUCHTTOD

Abstract

ABSTRACT Urinary Porter-Silber active 11-deoxycorticosteroids were determined in 12 healthy nonpregnant women (mean m = 0.07 mg/24 h; standard deviation s = ± 0.03), 13 patients with intrauterine foetal death in late pregnancy (m = 0.08 mg/24 h; s = ± 0.03) and in 15 women in the last weeks of an intact pregnancy (m = 0.21 mg/24 h; s = ± 0.09). The mean value in late pregnant women was significantly higher than in non-pregnant women (P < 0.001) or in women with foetal death (P < 0.001). The increase may be due to the changed metabolism or to the reduced inactivation into cortisol derivatives caused by pregnancy and/or to the increased production of cortisol. In cases of foetal death in late pregnancy the increase was not to be observed. In 2 pregnant women the increase during pregnancy and the decrease to the level of nonpregnant women after delivery was followed.