Light-triggered cardiac microphysiological model-Reference-Cited by-同舟云学术

Light-triggered cardiac microphysiological model

Published:2023-05-23 Issue:2 Volume:7 Page:
ISSN:2473-2877
Container-title:APL Bioengineering
language:en
Short-container-title:

Author:

Vurro V.¹^ORCID,Shani K.²^ORCID,Ardoña H. A. M.²³^ORCID,Zimmerman J. F.²^ORCID,Sesti V.¹²³⁴^ORCID,Lee K. Y.²³⁴⁵^ORCID,Jin Q.²^ORCID,Bertarelli C.¹²³⁴^ORCID,Parker K. K.²^ORCID,Lanzani G.¹⁶^ORCID

Affiliation:

1. Center for Nanoscience and Technology, Istituto Italiano di Teconologia 1 , Milano, 20133 Italy

2. Disease Biophysics Group, John A. Paulson School of Engineering and Applied Science, Harvard University 2 , Boston, Massachusetts 02134, USA

3. Department of Chemical and Biomolecular Engineering, Samueli School of Engineering, University of California 3 , Irvine, California 92697, USA

4. Department of Chemistry, Materials and Chemical Engineering “Giulio Natta” Politecnico di Milano 4 , Milano, 20133 Italy

5. Department of Integrative Bioscience and Biotechnology, Sejong University 5 , Seoul, South Korea

6. Department of Physics 6 , Politecnico di Milano, Milano, 20133 Italy

Abstract

Light is recognized as an accurate and noninvasive tool for stimulating excitable cells. Here, we report on a non-genetic approach based on organic molecular phototransducers that allows wiring- and electrode-free tissue modulation. As a proof of concept, we show photostimulation of an in vitro cardiac microphysiological model mediated by an amphiphilic azobenzene compound that preferentially dwells in the cell membrane. Exploiting this optical based stimulation technology could be a disruptive approach for highly resolved cardiac tissue stimulation.

Funder

Alberta Newsprint Company

American Chemical Society

Publisher

AIP Publishing

Subject

Biomedical Engineering,Biomaterials,Biophysics,Bioengineering

Link

https://pubs.aip.org/aip/apb/article-pdf/doi/10.1063/5.0143409/17795189/026108_1_5.0143409.pdf

Reference75 articles.

1. Novel interfaces for light directed neuronal stimulation: advances and challenges

2. Taking orders from light: progress in photochromic bio-materials

3. Shedding Light on Living Cells

4. A review of optical pacing with infrared light

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