1. Kenneth S. Pitzer Theory Center and Department of Chemistry, University of California 1 , Berkeley, California 94720, USA
2. Molecular Medicine Program, Hospital for Sick Children 2 , Toronto, Ontario M5S 1A8, Canada
3. Department of Biochemistry, University of Toronto 3 , Toronto, Ontario M5G 1X8, Canada
4. Department of Bioengineering and Chemical and Biomolecular Engineering, University of California 4 , Berkeley, California 94720, USA