SUPPLY OF THE ORGANISM WITH VITAMIN A UNDER CONDITIONS OF DIETARY PROTEIN DEFICIENCY AND TOXIC INJURY WITH ACETAMINOPHEN IN RATS

Abstract

The paper presents studies of the content of retinol and retinyl esters in the liver and serum of rats under conditions of acetaminophen-induced lesions and alimentary protein deficiency. During the experiment, the animals consumed a semi-synthetic diet of AIN-93. Simulation of acute toxic damage was carried out by per os administration of acetaminophen to rats at the rate of 1250 mg/kg of animal weight. It was found that under the simulated experimental conditions – protein deficiency and toxic damage by acetaminophen – there is a decrease in retinol in the serum of rats with minimal values when entering the body of medicinal xenobiotics, regardless of the amount of dietary protein. An increase in the content of retinoids (retinol and retinyl esters) has been reported in the liver of rats under the conditions of alimentary protein deprivation, which is probably aimed at maintaining the level of vitamin A in the blood. Toxicity with acetaminophen, regardless of dietary protein intake, is a key factor in reducing retinol and retinyl esters levels in rat liver. Under conditions of consumption of a low-protein diet in the body of rats, redistribution of retinoids occurs: an increase in the content of retinol and its storage forms in the liver with a simultaneous decrease in the level of retinol in the blood serum can probably be considered as a prerequisite for the mobilization of vitamin A into the bloodstream.