Affiliation:
1. From the Gates and Crellin Laboratories of Chemistry, California Institute of Technology, Pasadena. Dr. Jacobson is a Postdoctoral Fellow of the American Cancer Society.
Abstract
N-Acetylaspartic acid (NAA) occurs at relatively high concentrations exclusively in the mammalian and avian brain and undergoes rapid rise in level soon after birth (Tallan, 1957).
The amount of NAA in brains of mentally abnormal human beings and of young human beings was measured. The route by which NAA is synthesized was shown to involve a direct acetylation of aspartic acid. The degradative activity of the brain toward NAA is slight. Some experiments indicate that NAA in the brain is a physiologically and metabolically active compound.
Publisher
Rockefeller University Press
Cited by
98 articles.
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