Elucidating the clandestine behavior of enantiomeric DHPs in calcium channels-Reference-Cited by-同舟云学术

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Elucidating the clandestine behavior of enantiomeric DHPs in calcium channels

Published:2023-10-13 Issue:11 Volume:155 Page:
ISSN:0022-1295
Container-title:Journal of General Physiology
language:en
Short-container-title:

Author:

Smith Nathaniel¹²^ORCID,Sun Han¹²^ORCID

Affiliation:

1. Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) 1 , Berlin, Germany

2. Institute of Chemistry, Technical University of Berlin 2 , Berlin, Germany

Abstract

Computational study suggests that π-bulges play an integral role in the gating mechanisms of Cav channels, governing the binding of enantiomeric DHP.

Funder

Leibniz-Forschungsinstitut für Molekulare Pharmakologie

Publisher

Rockefeller University Press

Subject

Physiology

Link

https://rupress.org/jgp/article-pdf/doi/10.1085/jgp.202313481/1919426/jgp_202313481.pdf

Reference10 articles.

1. Modulation of pore opening of eukaryotic sodium channels by π-helices in S6;Choudhury;J. Phys. Chem. Lett.,2023

2. An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine;Choudhury;Biophys. J.,2022

3. Evolutionary origin of a secondary structure: π-Helices as cryptic but widespread insertional variations of α-helices that enhance protein functionality;Cooley;J. Mol. Biol.,2010

4. Structural basis of the modulation of the voltage-gated calcium ion channel Cav 1.1 by dihydropyridine compounds;Gao;Angew. Chem. Int. Ed. Engl,2021

5. L-type calcium channels: The low down;Lipscombe;J. Neurophysiol,2004

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