Prospects of using probiotics containing <i>Lactobacillus acidophilus</i> in the prevention and treatment of gastrointestinal diseases

Abstract

Aim theoretical analysis and systematization of the knowledge on using probiotics containingLactobacillus acidophilusin the prevention and treatment of diseases of the gastrointestinal tract. The bibliographic databases of the scientific libraries eLIBRARY.RU, Cochrane Library and CyberLeninka, the electronic resources of the Global Health platform, the sites of scientific publications ScienceDirect and Elsevier, MEDLINE and PubMed-NCBI were searched for the relevant information. Next, the full-text sources were analysed. We used structural-logical and analytical methods in this work. The probiotics containingLactobacillus acidophiluswere reported to enhance eradication therapy in the presence ofHelicobacter pyloriinfection, reduce pain and normalize bowel function in irritable bowel syndrome, normalize liver function, reduce liver enzymes, prevent the development of hepatic encephalopathy in non-alcoholic fatty liver disease, support clinical remission in ulcerative colitis. Also, they demonstrated the effectiveness for the prevention and treatment of antibiotic-associated diarrhea, including clostridial infection, and the improvement of intestinal microbiota. In many gastrointestinal diseases, the effect of probiotics had a high level of evidence. The beneficial properties of probiotics can be used in the development of functional food products for therapeutic and prophylactic purposes.