A Critical Review on Advances in the Multicomponent Synthesis of Pyrroles

Abstract

Nitrogen containing heterocyclic compounds are biologically significant molecules. This is especially true for pyrrole a five membered nitrogen containing aromatic molecule, which is present as a key structural motif in a large number of drugs and lead molecules. This review aims to provide an overview of the multi-component reaction (MCR) based methodologies used for the synthesis of pyrrole and its derivatives, focusing particularly on eco-friendly methods that avoid the use of hazardous reagents, solvents and catalysts are deemed especially relevant to the disciplines of medicinal chemistry and drug discovery.