Base‐Promoted Synthesis of N−H Free Pyrroles <i>via</i> net [3+2]‐Cycloaddition-Reference-Cited by-同舟云学术

Base‐Promoted Synthesis of N−H Free Pyrroles via net [3+2]‐Cycloaddition

Published:2023-11-13 Issue: Volume: Page:
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Jin Huimin¹²³,Zhou Fan¹²³,Xiang Zhenhua¹²³,Chen Lingfeng¹,Liang Guang¹,Walsh Patrick J.⁴^ORCID,Li Jie¹⁴²³

Affiliation:

1. School of Pharmaceutical Sciences Hangzhou Medical College Hangzhou Zhejiang 311399 People's Republic of China

2. Department of Pharmacy School of Medicine Hangzhou City University No. 48, Huzhou Road Hangzhou 310015 People's Republic of China

3. College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 People's Republic of China

4. Roy and Diana Vagelos Laboratories Department of Chemistry University of Pennsylvania 231 South 34th Street Philadelphia Pennsylvania 19104-6323 USA

Abstract

AbstractA base‐promoted net‐[3+2] cycloaddition of nitriles and 1‐arylpropynes for the synthesis of pyrroles is described. The developed method provides convenient access to various 2,5‐disubstituted or 2,4,5‐trisubstituted pyrroles in 40% to 96% yields (32 examples). Among methods for the synthesis of pyrroles, the protocol presented here stands out for its convenience and atom‐economy.

Funder

National Natural Science Foundation of China

National Science Foundation

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202301053

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