“Anti-microbial Study and Synthesis of Schiff bases of 3-actyl 4-hydroxy Quinolin-2-one”-Reference-Cited by-同舟云学术

“Anti-microbial Study and Synthesis of Schiff bases of 3-actyl 4-hydroxy Quinolin-2-one”

Published:2023-02-28 Issue:1 Volume:39 Page:197-201
ISSN:2231-5039
Container-title:Oriental Journal Of Chemistry
language:en
Short-container-title:Orient. J. Chem

Author:

Anjanikar Shivraj S.¹^ORCID,Chandole Santosh S.²^ORCID

Affiliation:

1. 1Department of Chemistry, Sharadchandra College, Naigaon, District- Nanded MS- 431709, India.

2. 2Department of Chemistry, S.G.B. College, Purna Jn., MS- 431511, India, (Affilated to Swami Ramanand Teerth Marathwada University, Nanded) India.

Abstract

Quinoline based new Schiff bases were synthesized from 3-Actyl 4-Hydroxy Quinolin-2-(1H)-one and screened their antibacterial and antifungal activity. The Schiff bases 4-hydroxy-3-(1-((4-picolin-2-yl)imino)ethyl)quinolin-2-(1H)-one(L1),4-hydroxy-3-(1-((5-picolin-2-yl)imino)ethyl)quinolin-2(1H)-one(L2),4-hydroxy-3-(1-((6-picolin-2-yl)-imino)ethyl)quinolin-2(1H)-one(L3) and 4-hydroxy-3-(1-((3-nitro-4-picolin-2-yl)imino)ethyl)quinolin-2-(1H)-one (L4) were preparedfrom 3-Acetyl 4-Hydroxy Quinolin-2-One with 2-amino picolines. The structures of Schiff bases were confirmed by Infrared, mass, proton-NMR and 13CNMR spectral analysis. In vitro studies of these Schiff bases were carried out for their antibacterial activity by Agar contact method and antifungal activity by the poison plate method. The bacterial species used were B. subtilis, E. coli, S. typhi, and S. aureus. Fungal species used were F. moneliforme, A.niger, A. flavus, and P. chrysogenum.

Publisher

Oriental Scientific Publishing Company

Subject

Drug Discovery,Environmental Chemistry,Biochemistry,General Chemistry

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