Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

Author:

Barreca Maria Letizia1,Manfroni Giuseppe1,Leyssen Pieter2,Winquist Johan3,Kaushik-Basu Neerja4,Paeshuyse Jan2,Krishnan Ramalingam4,Iraci Nunzio1,Sabatini Stefano1,Tabarrini Oriana1,Basu Amartya4,Danielson U. Helena3,Neyts Johan2,Cecchetti Violetta1

Affiliation:

1. Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Farmaceutica II, Università degli Studi di Perugia, Via del Liceo 1, 06123 Perugia, Italy

2. Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

3. Department of Chemistry—BMC, Uppsala University, Box 576, SE-751 23 Uppsala, Sweden

4. Department of Biochemistry and Molecular Biology, UMDNJ—New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference47 articles.

1. Epidemiology of Hepatitis C Virus (HCV) Infection

2. Factsheet No. 164, July 2011;World Health Organization:Geneva, 2011; http://www.who.int/mediacentre/factsheets/fs164/en/(accessed September 30, 2012).

3. New Merck and Vertex drugs raise standard of care in hepatitis C

4. Impact of HCV protease-inhibitor-based triple therapy for chronic HCV genotype 1 infection

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