Anti-diabetic Activity of Spirulina and Chlorella in In vivo Experimental Rats
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Published:2024-06-25
Issue:2
Volume:17
Page:903-913
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ISSN:2456-2610
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Container-title:Biomedical and Pharmacology Journal
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language:en
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Short-container-title:Biomed. Pharmacol. J.
Author:
Shaman Amani Ali1ORCID, Zidan Nahla S.2ORCID, Alzahrani Sharifa3, AlBishi Laila A.4, Sakran Mohamed I.5ORCID, Almutairi Fahad M.6ORCID, Keshk Ali A.6ORCID
Affiliation:
1. 1Faculty of Medicine, , University of Tabuk, Tabuk, Kingdom of Saudi Arabia 2. 2Faculty of science, food Science and Nutrition Dept, University of Tabuk, Tabuk, Saudi Arabia 3. 4Pharmacology Department, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia 4. 5Pediatric Department, Faculty of Medicine,University of Tabuk, Tabuk,Saudi Arabia 5. 7Biochemistry Section, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt 6. 8Department of Chemistry, Faculty of s, University of Tabuk, Tabuk 71491, Saudi Arabia
Abstract
The effects of supplying experimental rats with unicellular green algae Chlorella and tiny filamentous cyanobacteria Spirulina, on type 2 diabetes (T2DM) were examined in the present study. Eight sets of male Sprague-Dawley albino rats, each with six individuals, were used in the investigation. Throughout the trial, Group 1 was the negative control group and was given saline regularly. Group 2 was given alloxan to induce diabetes. Spirulina was given to groups 3, 4, and 5 at dosages of 100, 200, and 300 mg/kg body weight, respectively, after diabetes induction. Similarly, groups 6, 7, and 8 received dosages of 100, 200, and 300 mg/kg body weight of Chlorella, respectively. The findings indicated that the control group had significantly higher levels of triglycerides, low-density lipoprotein (LDL), blood sugar, and very low-density lipoprotein (VLDL) and considerably lower levels of insulin, high-density lipoprotein (HDL), and phospholipids. However, rats given Spirulina (groups 3, 4, and 5) showed notably higher insulin, HDL, and phospholipids levels and significantly lower blood glucose, cholesterol, VLDL, LDL, and triglycerides levels. Rats fed with Chlorella (groups 6, 7, and 8) also showed increased effectiveness of feed ratios, greater final weights, and body weight growth percentages compared to the control group. The present study shows that supplementing with Spirulina and Chlorella improves insulin lipid patterns, blood sugar, and type 2 diabetes in vivo laboratory rats. According to the research, Spirulina and Chlorella may be used as functional meals to help control and cure diabetes.
Funder
University of Tabuk
Publisher
Oriental Scientific Publishing Company
Reference38 articles.
1. 1. Eizirik, D.L.; Pasquali, L.; Cnop, M. Pancreatic _-cells in type 1 and T2DM mellitus: Different pathways to failure. Nat. Rev. Endocrinol. 2020, 16, 349–362. 2. 2. Ormazabal, V., Nair, S., Elfeky, O. et al. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol 17, 122 (2018). https://doi.org/10.1186/s12933-018-0762-4. 3. 3. Ramos-Romero, S.; Hereu, M.; Atienza, L.; Casas, J.; Jáuregui, O.; Amézqueta, S.; DaSilva, G.; Medina, I.; Nogués, M.R.; Romeu, M.; et al. Mechanistically different effects of fat and sugar on insulin resistance, hypertension, and gut microbiota in rats. Am. J. Physiol. Metab. 2018, 314, E552–E563. 4. 4. Forouhi NG, Wareham NJ. Epidemiology of diabetes. Medicine. 2019;47(1):22–7. 5. 5. Tejero Pérez A, Kapravelou G, Porres Foulquie JM, López Jurado Romero de la Cruz M, Martínez Martínez R. Potential benefits of microalgae intake against metabolic diseases: beyond spirulina-a systematic review of animal studies. Nutr Rev. 2023 Aug 29:nuad098. doi: 10.1093/nutrit/nuad098. Epub ahead of print. PMID: 37643736.
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