Antioxidant and photoprotective potential of Polypodium leucotomos

Author:

Cruz Rosy Yesela Mancilla Santa1ORCID,Arévalo Sharon Velásquez2ORCID,Rashid Anas3ORCID,Jara Marco Rolando Aronés4ORCID,Prado María Segunda Aurora5ORCID

Affiliation:

1. Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil; Professional School of Pharmacy and Biochemistry, Faculty of Health Sciences, National University of San Cristóbal of Huamanga, Ayacucho 05001, Peru

2. Department of Pharmacotechnics, Faculty of Pharmacy and Biochemistry, National University of Trujillo, Trujillo 13011, Peru

3. Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil; School of Medicine and Surgery, University of Torino, Torino 10125, Italy

4. Professional School of Pharmacy and Biochemistry, Faculty of Health Sciences, National University of San Cristóbal of Huamanga, Ayacucho 05001, Peru

5. Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil

Abstract

In recent years, Polypodium leucotomos has emerged with a great interest for having medicinal and therapeutic potential. It is producing very promising results due to the presence of antioxidant and photoprotective properties. Electronic libraries and databases, including Scopus, PubMed, Google Scholar, Science Direct, and Web of Science were searched to identify relevant studies; 79 publications contributed to this review regarding Polypodium leucotomos botanical aspects, chemical composition, antioxidant and photoprotective activity. It is used in complementary and alternative therapies with various pharmaceutical dosage forms (systemic or topical). Thanks to the composition of phytochemical constituents present in the leaves and rhizomes which confer antioxidant and photoprotective activity that has clinical therapeutic potential to be used as systemic and topical sunscreen of natural origin for the prevention of different types of skin diseases caused by harmful ultraviolet A and ultraviolet B radiations. However, more studies are needed in the future to test the ability and enhance the capacity of sunscreen and sunblock in cosmetic formulations. To conclude, it is recommended to carry out scientific studies based on different analytical methods to evaluate the phytoconstituents potential and to develop stable pharmaceutical formulations according to the skin phototype.

Publisher

Open Exploration Publishing

Subject

General Medicine

Reference79 articles.

1. Horvath A, Alvarado F, Szöcs J, de Alvardo ZN, Padilla G. Metabolic effects of calagualine, an antitumoral saponine of Polypodium leucotomos. Nature. 1967;214:1256–8.

2. Choudhry SZ, Bhatia N, Ceilley R, Hougeir F, Lieberman R, Hamzavi I, et al. Role of oral Polypodium leucotomos extract in dermatologic diseases: a review of the literature. J Drugs Dermatol. 2014;13:148–53.

3. Efectos del extracto de Polypodium leucotomos sobre la tumorogénesis inducida por la radiación ultravioleta [Internet]. Theses and Dissertations Online; [cited 2022 Sep 9]. Available from: http://hdl.handle.net/10803/8754

4. Nogal-Ruiz JJ, Gómez-Barrio A, Escario JA, Martínez-Fernández AR. Effect of Anapsos in a murine model of experimental trichomoniasis. Parasite. 2003;10:303–8.

5. Garcia F, Pivel JP, Guerrero A, Brieva A, Martinez-Alcazar MP, Caamano-Somoza M, et al. Phenolic components and antioxidant activity of Fernblock, an aqueous extract of the aerial parts of the fern Polypodium leucotomos. Methods Find Exp Clin Pharmacol. 2006;28:157–60.

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