Affiliation:
1. Lahore Grammar School, Lahore 54792, Pakistan
2. Stanford Neurosciences Interdepartmental Program, Stanford University School of Medicine, Stanford, CA 94305, USA
Abstract
Post-translational modifications (PTMs) of alpha-synuclein (α-syn) can alter protein aggregation propensity to affect α-syn oligomer and fibril formation. The inflammatory response in Parkinson’s disease (PD) is mediated by microglia, astrocytes, T cells, B cells, macrophages, and neutrophils, which respond to α-syn aggregates in an attempt to clear synucleinopathy and restore brain homeostasis. This review focuses on the effects of PTMs on α-syn aggregation and cell-specific immune responses to α-syn aggregates in the context of PD.
Publisher
Open Exploration Publishing
Subject
General Medicine,General Medicine,Ocean Engineering,Safety, Risk, Reliability and Quality,General Medicine,Electrical and Electronic Engineering,Atomic and Molecular Physics, and Optics,General Medicine,Immunology,General Medicine,General Earth and Planetary Sciences,General Environmental Science,Materials Science (miscellaneous)