Inhibition of Staphylococcus aureus by Potassium Sorbate in Combination with Sodium Chloride, Tertiary Butylhydroquinone, Butylated Hydroxanisole or Ethylenediamine Tetraacetic Acid

Abstract

The effect of potassium sorbate alone and combined with sodium chloride (NaCl), tertiary butylhydroquinone (TBRQ). butylated hydroxyanisole (BHA) or ethylenediamine tetraacetic acid (EDTA) on growth of two strains of Staphylococcus aureus (S-6 and 12600) was studied. The growth studies were made using trypticase soy broth (pH 6.0) at 37 C. Certain combinations of sorbate with NaCl resulted in synergistic inhibition of growth of both strains. The combination of sorbate and TBRQ also resulted in synergistic inhibition of growth of strain 12600, but 25 ppm of TBRQ alone inhibited growth of strain S-6. Certain combinations of sorbate and BHA were synergistic against growth of both strains. Addition of EDTA did not potentiate sorbate's activity against growth of strain S-6 but was synergistic with sorbate against growth of strain 12600.