Abstract
ABSTRACT
Objective: To investigate the histopathological and clinical pattern of glomerular diseases in children. Method: A cross - sectional descriptive study was conducted on 71 children with glomerular disease who underwent kidney biopsy from January 2020 to December 2022.
Results: Pure nephrotic syndrome was the main diagnosis before kidney biopsy (59.3%), followed by non - pure nephrotic syndrome with 12.7%, Schonlein Henoch nephritis, Lupus nephritis, IgA nephropathy, accounting for 11.2%, 8.4%, 5.6%, respectively. Hemolytic uremic syndrome and Alport syndrome accounted for 1.4% of each type. After being diagnosed by histopathological results, minimal change disease was most common with 36.6% in the primary group, and Lupus nephritis was found mainly with 15.5% in the secondary group. Among the clinical manifestations of glomerular diseases, hematuria, and extrarenal manifestations were significantly different among the glomerular groups (p < 0.05). The ratio of change in diagnosis after the renal biopsy was 38%, in which IgA nephropathy had the lowest ratio, and Lupus nephritis and nephrotic syndrome had the highest ratio.
Conclusions: Minimal change disease predominated in the group of primary glomerular disease, and Lupus nephritis was the majority in the group of secondary glomerulonephritis. Hematuria and extrarenal manifestations were clinically significant differences among groups of glomerular diseases.