Long-Term Risk for Major Bleeding During Extended Oral Anticoagulant Therapy for First Unprovoked Venous Thromboembolism

Author:

Khan Faizan1ORCID,Tritschler Tobias2ORCID,Kimpton Miriam3,Wells Philip S.3ORCID,Kearon Clive4,Weitz Jeffrey I.4,Büller Harry R.5,Raskob Gary E.6,Ageno Walter7,Couturaud Francis8ORCID,Prandoni Paolo9,Palareti Gualtiero9ORCID,Legnani Cristina9ORCID,Kyrle Paul A.10,Eichinger Sabine10,Eischer Lisbeth10,Becattini Cecilia11ORCID,Agnelli Giancarlo11,Vedovati Maria Cristina11,Geersing Geert-Jan12,Takada Toshihiko12ORCID,Cosmi Benilde13ORCID,Aujesky Drahomir2,Marconi Letizia14,Palla Antonio14,Siragusa Sergio15,Bradbury Charlotte A.16ORCID,Parpia Sameer17,Mallick Ranjeeta18,Lensing Anthonie W.A.19,Gebel Martin19,Grosso Michael A.20,Thavorn Kednapa1ORCID,Hutton Brian1ORCID,Le Gal Gregoire3,Fergusson Dean A.21ORCID,Rodger Marc A.22ORCID,

Affiliation:

1. University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (F.K., K.T., B.H.)

2. Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (T.T., D.A.)

3. Ottawa Hospital Research Institute, University of Ottawa, and The Ottawa Hospital, Ottawa, Ontario, Canada (M.K., P.S.W., G.L.)

4. McMaster University and Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada (C.K., J.I.W.)

5. Amsterdam University Medical Center, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands (H.R.B.)

6. University of Oklahoma Health Sciences Center, Hudson College of Public Health, Oklahoma City, Oklahoma (G.E.R.)

7. University of Insubria, Varese, Italy (W.A.)

8. Brest University Hospital, Brest, France (F.C.)

9. Arianna Foundation on Anticoagulation, Bologna, Italy (P.P., G.P., C.L.)

10. Medical University of Vienna, Vienna, Austria (P.A.K., S.E., L.E.)

11. University of Perugia, Perugia, Italy (C.B., G.A., M.C.V.)

12. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (G.G., T.T.)

13. Sant’Orsola-Malpighi University Hospital, Bologna, Italy (B.C.)

14. University of Pisa, Pisa, Italy (L.M., A.P.)

15. University of Palermo, Palermo, Italy (S.S.)

16. University of Bristol, Bristol, United Kingdom (C.A.B.)

17. McMaster University, Hamilton, Ontario, Canada (S.P.)

18. Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (R.M.)

19. Bayer, Wuppertal, Germany (A.W.L., M.G.)

20. Daiichi Sankyo, Basking Ridge, New Jersey (M.A.G.)

21. University of Ottawa, Ottawa Hospital Research Institute, and The Ottawa Hospital, Ottawa, Ontario, Canada (D.A.F.)

22. Ottawa Hospital Research Institute, Ottawa, Ontario, and McGill University, Montreal, Quebec, Canada (M.A.R.).

Funder

Canadian Institutes of Health Research

Publisher

American College of Physicians

Subject

General Medicine,Internal Medicine

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