Intercommunicating avenues – cytokine networks in psoriasis Mihaela Surcel1, Adriana Narcisa Munteanu12,

Abstract

Psoriasis is a systemic autoimmune disease in which skin’s cells, keratinocytes, are hyper-activated and would actively secrete various immune molecules inducing the disease’s immunopathogenesis. We are discussing herein the complex array of cytokine and chemokines that are intertwining and the mechanisms that are involved in Ps development along with our experience regarding the contribution of pro- and anti-inflammatory cytokines/chemokines in this autoimmune disease. We are presenting the cytokine network grouped by their action and regardless their origin, i.e. secreted by immune or non-immune cells. Moreover, we are discussing their molecular relationship that sustains cells’ cross-talk in the development of psoriasis.