Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review-Reference-Cited by-同舟云学术

Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review

Published:2022-04 Issue:3 Volume:23 Page:163-174
ISSN:1389-2029
Container-title:Current Genomics
language:en
Short-container-title:CG

Author:

Torkamandi Shahram¹,Mikaeili Haleh²,Sahebkar Amirhossein³⁴⁵,Babaie Farhad⁶⁷,Omraninava Melodi⁸,Gorabi Armita Mahdavi⁹,Khosrojerdi Arezou¹⁰,Aslani Saeed¹¹,Yazdchi Arsalan¹²,Sathyapalan Thozhukat¹³

Affiliation:

1. Department of Medical Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

2. Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

3. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

4. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

5. Department of Biotechnology, School of Pharmacy, Mashhad University of Western Australia, Mashhad, Iran

6. Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran

7. Department of Medical Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

8. Department of Infectious Diseases, Faculty of Medical Sciences, Sari Branch, Islamic Azad University, Sari, Iran

9. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

10. Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

11. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

12. Student Research Committee, Tehran University of Medical Sciences, Tehran, Iran

13. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK

Abstract

Abstract: Psoriasis is an organ-specific autoimmune disease characterized by the aberrant proliferation and differentiation of keratinocytes, leading to skin lesions. Abnormal immune responses mediated by T cells and dendritic cells and increased production of inflammatory cytokines have been suggested as underlying mechanisms in the pathogenesis of psoriasis. Emerging evidence suggests that there is a heritable basis for psoriatic disorders. Moreover, numerous gene variations have been associated with the disease risk, particularly those in innate and adaptive immune responses and antigen presentation pathways. Herein, this article discusses the genetic implications of psoriatic diseases' etiopathogenesis to develop novel investigative and management options.

Publisher

Bentham Science Publishers Ltd.

Subject

Genetics (clinical),Genetics

Reference133 articles.

1. Chandran V.; Raychaudhuri S.P.; Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis. J Autoimmun 2010,34(3),J314-J321

2. Lowes M.A.; Russell C.B.; Martin D.A.; Towne J.E.; Krueger J.G.; The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. Trends Immunol 2013,34(4),174-181

3. Mak R.; Hundhausen C.; Nestle F.; Progress in understanding the immunopathogenesis of psoriasis. Actas Dermo-Sifiliograficas 2009,100,2-13

4. Nickoloff B.J.; Nestle F.O.; Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J Clin Invest 2004,113(12),1664-1675

5. Zhou X.; Chen Y.; Cui L.; Shi Y.; Guo C.; Advances in the pathogenesis of psoriasis: From keratinocyte perspective. Cell Death Dis 2022,13(1),81

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis;International Journal of Molecular Sciences;2024-01-15

2. Dietary Fiber Inulin Improves Murine Imiquimod-Induced Psoriasis-like Dermatitis;International Journal of Molecular Sciences;2023-09-17

3. Genetic and Epigenetic Mechanisms of Psoriasis;Genes;2023-08-13