EFFECT OF ANGIOTENSIN-CONVERTING ENZYME GENE I/D POLYMORPHISM ON NEPHROPATHY IN DIABETIC PATIENTS-Reference-Cited by-同舟云学术

EFFECT OF ANGIOTENSIN-CONVERTING ENZYME GENE I/D POLYMORPHISM ON NEPHROPATHY IN DIABETIC PATIENTS

Published:2014-06-28 Issue:2 Volume: Page:35-40
ISSN:2708-6011
Container-title:Health and Ecology Issues
language:
Short-container-title:jour

Author:

Vasilkova O. N.¹,Silin A. E.²,Martinkov V. N.²,Tropashko I. B.²,Zekenova K. K.²,Zhmailik M. V.²,Mokhort T. V.³

Affiliation:

1. Gomel State Medical University

2. Republican Research Centre for Radiation Medicine and Human Ecology, Gomel

3. Belarusian State Medical University, Minsk

Abstract

Aim: to study the relation of angiotensin-converting enzyme ACE (I/D) in genetic susceptibility of diabetic nephropathy (DN). Methods. I/D polymorphism of ACE gene was studied in 58 patients with diabetes type 2. Results. There are no reliable differences in detection of DD genotype and D allele in patients with DN and without DN (40,9 and 52,3 %, 19,4 and 41,7 %, respectively) (p = 0,076, LR = 0,313, 95 % DI = 0,084-1,164 for DD and p = 0,266, LR = 0,631, 95 % DI = 0,303-1,312 for D). Conclusion. The comparison of the results of genotyping in patients with and without DN did not reveal any differences in distribution of allele and ACE genotypes.

Publisher

Gomel State Medical University

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