Insertion/Deletion Polymorphism of the ACE Gene Is Associated With Type 2 Diabetes-Reference-Cited by-同舟云学术

Insertion/Deletion Polymorphism of the ACE Gene Is Associated With Type 2 Diabetes

Published:2002-06-01 Issue:6 Volume:51 Page:1986-1988
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Feng Yan¹²,Niu Tianhua³,Xu Xin³,Chen Changzhong³,Li Qiongfang¹,Qian Rongli⁴,Wang Guoying¹²,Xu Xiping²³

Affiliation:

1. Division of Endocrinology, the Third Affiliated Hospital of Beijing University, Beijing, China

2. Center for Ecogenetics and Reproductive Health, Beijing University, Beijing, China

3. Program for Popular Genetics, Harvard School of Public Health, Boston, Massachusetts

4. Division of Endocrinology, the First Affiliated Hospital of Beijing University, Beijing, China

Abstract

In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (χ21 = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/51/6/1986/651099/db0602001986.pdf

Reference22 articles.

1. Harris MI: Newly Revised Classification and Diagnostic Criteria for Diabetes Mellitus. In Current Review of Diabetes. Taylor SI, Ed. Philadelphia, PA, Current Medicine,1999, p. 3

2. McCarthy M, Menzel S: The genetics of type 2 diabetes. Br J Clin Pharmacol 51:195–199,2001

3. Wong TY, Chan JC, Poon E, Li PK: Lack of association of angiotensin-converting enzyme (DD/II) and angiotensinogen M235T gene polymorphism with renal function among Chinese patients with type II diabetes. Am J Kidney Dis 33:1064–1070,1999

4. Schunkert H: Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease. J Mol Med 75:867–875,1997

5. Fujisawa T, Ikegami H, Shen GQ, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Ueda H, Rakugi H, Higaki J: Angiotensin I-converting enzyme gene polymorphism is associated with myocardial infarction, but not with retinopathy or nephropathy, in NIDDM. Diabetes Care 18:983–985,1995

Cited by 62 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Association of ACE*(Insertion/Deletion) Variant with the Elevated Risk of Preeclampsia Among Gestational Women;Biochemical Genetics;2024-01-14

2. Association of Angiotensin-I-Converting Enzyme (ACE) Insertion/ Deletion Gene Polymorphism with Preeclampsia Susceptibility in Egyptian women;2023-02-09

3. Editorial: Untangling energy metabolism in skeletal muscle: From physiology to pharmacology;Frontiers in Physiology;2022-12-14

4. Post-translational dysregulation of glucose uptake during exhaustive cycling exercise in vastus lateralis muscle of healthy homozygous carriers of the ACE deletion allele;Frontiers in Physiology;2022-09-06

5. Relationship between insertion/deletion (I/D) polymorphism of angiotensin converting enzyme (ACE) gene and susceptibility to type 2 diabetes mellitus in the Middle East and North Africa Region: A meta-analysis;Diabetes & Metabolic Syndrome: Clinical Research & Reviews;2022-01