Occupational and environmental exposure to SARS-CoV-2 in and around infected mink farms

Author:

de Rooij Myrna M TORCID,Hakze-Van der Honing Renate W,Hulst Marcel M,Harders Frank,Engelsma Marc,van de Hoef Wouter,Meliefste Kees,Nieuwenweg Sigrid,Oude Munnink Bas B,van Schothorst Isabella,Sikkema Reina S,van der Spek Arco N,Spierenburg Marcel,Spithoven Jack,Bouwstra Ruth,Molenaar Robert-Jan,Koopmans Marion,Stegeman Arjan,van der Poel Wim H M,Smit Lidwien A MORCID

Abstract

ObjectiveUnprecedented SARS-CoV-2 infections in farmed minks raised immediate concerns regarding transmission to humans and initiated intensive environmental investigations to assess occupational and environmental exposure.MethodsAir sampling was performed at infected Dutch mink farms, at farm premises and at nearby residential sites. A range of other environmental samples were collected from minks’ housing units, including bedding materials. SARS-CoV-2 RNA was analysed in all samples by quantitative PCR.ResultsInside the farms, considerable levels of SARS-CoV-2 RNA were found in airborne dust, especially in personal inhalable dust samples (approximately 1000–10 000 copies/m3). Most of the settling dust samples tested positive for SARS-CoV-2 RNA (82%, 75 of 92). SARS-CoV-2 RNA was not detected in outdoor air samples, except for those collected near the entrance of the most recently infected farm. Many samples of minks’ housing units and surfaces contained SARS-CoV-2 RNA.ConclusionsInfected mink farms can be highly contaminated with SARS-CoV-2 RNA. This warns of occupational exposure, which was substantiated by considerable SARS-CoV-2 RNA concentrations in personal air samples. Dispersion of SARS-CoV-2 to outdoor air was found to be limited and SARS-CoV-2 RNA was not detected in air samples collected beyond farm premises, implying a negligible risk of environmental exposure to nearby communities. Our occupational and environmental risk assessment is in line with whole genome sequencing analyses showing mink-to-human transmission among farm workers, but no indications of direct zoonotic transmission events to nearby communities.

Funder

Netherlands Ministry of Agriculture, Nature and Foods

Publisher

BMJ

Subject

Public Health, Environmental and Occupational Health

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