Abstract
Ubiquitin-specific protease 6(USP6) rearrangements have been identified in aneurysmal bone cyst, nodular fasciitis, myositis ossificans, fibro-osseous pseudotumour of digits and cellular fibroma of tendon sheath. These entities show clinical as well as histological overlap, suggesting they are all clonal neoplastic belonging to the same biological spectrum and referred to as ‘USP6-associated neoplasms’. They all show a characteristic gene fusion formed by juxtaposition of theUSP6coding sequences to the promoter regions of several partner genes, leading toUSP6transcriptional upregulation.
Subject
General Medicine,Pathology and Forensic Medicine
Cited by
4 articles.
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