New kids on the block:FOSandFOSBgene

Abstract

FOSandFOSBproto-oncogens are involved in a wide variety of tumourigenic processes.FOSandFOSBgene rearrangements are observed in epithelioid haemangioma, pseudomyogenic haemangioendothelioma, osteoid osteoma/osteoblastoma/cementoblastoma and proliferative myositis/fasciitis. In this review, we provide an overview ofFOSandFOSB,including their functions and the differences between lesions with knownFOS/FOSBgene rearrangements. Additionally, we discuss the use ofFOS/FOSBimmunohistochemistry as a diagnostic tool for these lesions.