Author:
Kelly-Cirino Cassandra,Mazzola Laura T,Chua Arlene,Oxenford Christopher J,Van Kerkhove Maria D
Abstract
Diagnostics play a central role in the early detection and control of outbreaks and can enable a more nuanced understanding of the disease kinetics and risk factors for the Middle East respiratory syndrome-coronavirus (MERS-CoV), one of the high-priority pathogens identified by the WHO. In this review we identified sources for molecular and serological diagnostic tests used in MERS-CoV detection, case management and outbreak investigations, as well as surveillance for humans and animals (camels), and summarised the performance of currently available tests, diagnostic needs, and associated challenges for diagnostic test development and implementation. A more detailed understanding of the kinetics of infection of MERS-CoV is needed in order to optimise the use of existing assays. Notably, MERS-CoV point-of-care tests are needed in order to optimise supportive care and to minimise transmission risk. However, for new test development, sourcing clinical material continues to be a major challenge to achieving assay validation. Harmonisation and standardisation of laboratory methods are essential for surveillance and for a rapid and effective international response to emerging diseases. Routine external quality assessment, along with well-characterised and up-to-date proficiency panels, would provide insight into MERS-CoV diagnostic performance worldwide. A defined set of Target Product Profiles for diagnostic technologies will be developed by WHO to address these gaps in MERS-CoV outbreak management.
Subject
Public Health, Environmental and Occupational Health,Health Policy
Reference132 articles.
1. Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
2. WHO , 2017. WHO | Middle East respiratory syndrome coronavirus (MERS-CoV). WHO MERS-COV. Available from: http://www.who.int/emergencies/mers-cov/en/ [Accessed 12 Sep 2017].
3. WHO , 2016. R&D Blueprint Plan of Action (2016). Available from: http://www.who.int/entity/blueprint/about/r_d_blueprint_plan_of_action.pdf [Accessed 12 Sep 2017].
4. WHO , 2017. R&D Blueprint for action to prevent epidemics.. Available from: http://www.who.int/blueprint/en/ [Accessed 12 Sep 2017].
5. MERS: Progress on the global response, remaining challenges and the way forward;Aguanno;Antiviral Res,2018
Cited by
37 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献