Prophylactic surfactant nebulisation for the early aeration of the preterm lung: a randomised clinical trial

Abstract

ObjectiveThe effect of prophylactic surfactant nebulisation (SN) is unclear. We aimed to determine whether prophylactic SN improves early lung aeration.DesignParallel, randomised clinical trial, conducted between March 2021 and January 2022.SettingDelivery room (DR) of a tertiary neonatal centre in Zurich, Switzerland.PatientsPreterm infants between 260/7and 316/7weeks gestationInterventionsInfants were randomised to receive positive distending pressure alone or positive distending pressure and additional SN (200 mg/kg; poractant alfa) using a customised vibrating membrane nebuliser. SN commenced with the first application of a face mask immediately after birth.Main outcome measuresPrimary outcome was the difference in end-expiratory lung impedance from birth to 30 min after birth (∆EELI30min). EELI correlates well with functional residual capacity. Secondary outcomes included physiological and clinical outcomes.ResultsData from 35 infants were collected, and primary outcome data were analysed from 32 infants (n=16/group). Primary outcome was not different between intervention and control group (median (IQR): 25 (7–62) vs 10 (0–26) AU/kg, p=0.21). ∆EELI was slightly higher in the intervention group at 6 and 12 hours after birth, particularly in the central areas of the lung. There were no differences in cardiorespiratory and clinical parameters. Two adverse events were noted in the intervention group.ConclusionsProphylactic SN in the DR did not significantly affect ∆EELI30minand showed only minimal effects on lung physiology. Prophylactic SN in the DR was feasible. There were no differences in clinical outcomes.Trial registration numberNCT04315636.