Genomic Risk Score impact on susceptibility to systemic sclerosis

Author:

Bossini-Castillo Lara,Villanueva-Martin GonzaloORCID,Kerick Martin,Acosta-Herrera Marialbert,López-Isac Elena,Simeón Carmen P,Ortego-Centeno Norberto,Assassi ShervinORCID,Hunzelmann Nicolas,Gabrielli Armando,de Vries-Bouwstra J K,Allanore YannickORCID,Fonseca Carmen,Denton Christopher PORCID,Radstake Timothy RDJ,Alarcón-Riquelme Marta Eugenia,Beretta LorenzoORCID,Mayes Maureen D,Martin Javier, , , ,

Abstract

ObjectivesGenomic Risk Scores (GRS) successfully demonstrated the ability of genetics to identify those individuals at high risk for complex traits including immune-mediated inflammatory diseases (IMIDs). We aimed to test the performance of GRS in the prediction of risk for systemic sclerosis (SSc) for the first time.MethodsAllelic effects were obtained from the largest SSc Genome-Wide Association Study (GWAS) to date (9 095 SSc and 17 584 healthy controls with European ancestry). The best-fitting GRS was identified under the additive model in an independent cohort that comprised 400 patients with SSc and 571 controls. Additionally, GRS for clinical subtypes (limited cutaneous SSc and diffuse cutaneous SSc) and serological subtypes (anti-topoisomerase positive (ATA+) and anti-centromere positive (ACA+)) were generated. We combined the estimated GRS with demographic and immunological parameters in a multivariate generalised linear model.ResultsThe best-fitting SSc GRS included 33 single nucleotide polymorphisms (SNPs) and discriminated between patients with SSc and controls (area under the receiver operating characteristic (ROC) curve (AUC)=0.673). Moreover, the GRS differentiated between SSc and other IMIDs, such as rheumatoid arthritis and Sjögren’s syndrome. Finally, the combination of GRS with age and immune cell counts significantly increased the performance of the model (AUC=0.787). While the SSc GRS was not able to discriminate between ATA+ and ACA+ patients (AUC<0.5), the serological subtype GRS, which was based on the allelic effects observed for the comparison between ACA+ and ATA+ patients, reached an AUC=0.693.ConclusionsGRS was successfully implemented in SSc. The model discriminated between patients with SSc and controls or other IMIDs, confirming the potential of GRS to support early and differential diagnosis for SSc.

Funder

Ministerio de Ciencia e Innovación

Innovative Medicines Initiative

Instituto de Salud Carlos III

Publisher

BMJ

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,Immunology and Allergy,Rheumatology

Reference43 articles.

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