The effect of complex therapy of cows with genital mycoplasmosis on indicators of nonspecific resistance

Abstract

Animal husbandry on an industrial basis involves the maximum use of the reproductive capabilities of females and obtaining healthy offspring. A significant obstacle to achieving this goal are diseases that negatively affect the reproductive function of females, one of which is genital mycoplasmosis of cattle. The basis of etiotropic therapy of mycoplasmosis is the use of macrolide and fluoroquinolone antibiotics, but at the same time the animals remain immunodeficient. The aim of our research was to assess the dynamics of indicators of nonspecific resistance of the organism of patients with genital mycoplasmosis of cows when the immunomodulator thymalin was included in the treatment regimen. Studies were carried out on three groups of pregnant cows, the first group of animals with mycoplasmosis was treated with tulatromycin, the second group was treated with tulatromycin in combination with thymalin, the third group was clinically healthy cows. The results of the experiment showed that the combined use of tulatromycin and thymalin in genital mycoplasmosis of cattle, compared with monotherapy with tulatromycin, increases therapeutic efficacy by 25%, and also contributes to a significant increase in bactericidal and lysozyme activity of blood serum, phagocytic index, which even slightly exceed similar indicators in clinically healthy animals.