Author:
Hara Yasuhiro, ,Yamada Masahiro,Tatsukawa Chikako,Takahashi Tomokazu,Suzuki Masato,Aoyagi Seiji, ,
Abstract
The demand for minimally invasive injection needles or needle-shaped tools is growing from those who carry out medical practices such as blood or insulin injections. Applying the mosquito biomimetic, we have used a femtosecond laser to fabricate minimally invasive microneedles out of ultrafine hollow SUS304 pipes, 50μm in outer diameter and 20μm in inner diameter. When such a stainless steel needle tip is angled at 15°, it has the lowest penetration resistance, two and a half times lower than that of the finest hollow needle that is commercially available. A blood suction experiment with a newly developed microneedle has demonstrated that 2.8μellof blood can be drawn out in 20 seconds. Such stainless steel microneedles fabricated by femtosecond lasers have great potential as minimally invasive and mass-producible blood sampling needles to be used for diabetic inspections.
Publisher
Fuji Technology Press Ltd.
Subject
Industrial and Manufacturing Engineering,Mechanical Engineering
Reference19 articles.
1. P. K. Campbell, K. E. Jones, R. J. Huber, K. W. Horch, and R. A. Normann, “A Silicon-Based, Three-Dimensional Neural Interface: Manufacturing Processes for an Intracortical Electrode Array,” IEEE Trans. Biomed. Eng., Vol.38, No.8, pp. 758-768, 1991.
2. K. Najafi, J. Ji, and K. D. Wise, “Scaling Limitations of Silicon Multichannel Recording Probes,” J. Biomed. Eng., Vol.37, No.1, pp. 1-11, 1990.
3. S. Chandrasekaran, J. D. Brazzle, and A. B. Frazier, “Surface Micromachined Metallic Microneedles,” J. MEMS, Vol.12, No.3, pp. 281-288, 2003.
4. D. V. McAllister, F. Cross, S. P. Davis, L. M. Matta, M. R. Prausnitz, and M. G. Allen, “Three-Dimensional Hollow Microneedle and Microtube Arrays,” Proc. Transducers’ 99, pp. 1098-1101, 1999.
5. J. Park, S. Davis, Y. Yoon, M. R. Prausnitz, and M. G. Allen, “Micromachined Biodegradable Microstructures,” Proc. MEMS ’03, pp. 371-374, 2003.
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献