Therapy for neurodegenerative Diseases and expectations

Abstract

The current development of genetic engineering has been able to intervene in the treatment of many disease areas, especially immune diseases have shown the need for gene editing. The importance of target correspondence is evident at all stages of research. Neurodegenerative diseases have always been a struggling area of medicine, but the current mainstream gene-based immunotherapy has given people the possibility of curing or improving neurological diseases. In the investigation and deepening understanding, at least one immunotherapy has practical application, but the other has not shown the achievements in the direction of neurobiology. Even though immunotherapy is indelible, especially in cancer tumors, the more possibilities of these therapies and the progress of current development are worthy of attention and repeated research. CRISPR therapy is not only able to effectively insert and modify or knock out targeted gene segments in treatment; it is also used to discover the pathogenesis of certain diseases, the pathogenesis suspected by scientists, such as whether the expression level of a certain protein That can be controlled by increasing or decreasing gene expression, both achievable through the implementation of CRISPR therapies. In this review, we summarizes CAR-T and CRISPR therapies in Alzheimer's Disease.