Challenges and limitations of using ventilator-free days as an outcome in critical care trials
Author:
Affiliation:
1. Pontificia Universidad Católica de Chile, Chile
2. HCor-Hospital do Coração, Brazil
Publisher
Associação de Medicina Intensiva Brasileira
Link
https://criticalcarescience.org/wp-content/uploads/sites/7/articles_xml/2965-2774-ccsci-36-e20240088en/2965-2774-ccsci-36-e20240088en.pdf
Reference12 articles.
1. Protocol-directed weaning versus conventional weaning from mechanical ventilation for neurocritical patients in an intensive care unit: a nonrandomized quasi-experimental study;Belenguer-Muncharaz A;Crit Care Sci,2023
2. Statistical analysis of a cluster-randomized clinical trial on adult general intensive care units in Brazil: TELE-critical care verSus usual Care On ICU PErformance (TELESCOPE) trial;Ranzani O;Rev Bras Ter Intensiva,2022
3. Reappraisal of ventilator-free days in critical care research;Yehya N;Am J Respir Crit Care Med,2019
4. Alive and ventilator free: a hierarchical, composite outcome for clinical trials in the acute respiratory distress syndrome;Novack V;Crit Care Med,2020
5. Sample size estimation in clinical trials using ventilator-free days as the primary outcome: a systematic review;Renard Triché L;Crit Care,2023
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