Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

Author:

Hanson Leah R,Frey William H

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,General Neuroscience

Reference34 articles.

1. Dhanda DS, Frey WH, Leopold D, Kompella UB: Approaches for drug deposition in the human olfactory epithelium. Drug Delivery Technol. 2005, 5: 64-72.

2. Frey WH: Bypassing the blood-brain barrier to delivery therapeutic agents to the brain and spinal cord. Drug Delivery Technol. 2002, 5: 46-49.

3. Frey WH: (WO/1991/007947) Neurologic Agents for Nasal Administration to the Brain (priority date 5.12.89). 1991, Geneva, Switzerland: World Intellectual Property Organization, [ http://www.wipo.int/pctdb/en/wo.jsp?wo=1991007947&IA=WO1991007947&DISPLAY=CLAIMS ]

4. Thorne RG, Emory CR, Ala TA, Frey WH: Quantitative assessment of protein transport to the rat olfactory bulb following intranasal administration: implications for drug delivery. Brain Res. 1995, 692: 278-282. 10.1016/0006-8993(95)00637-6.

5. Chen X-Q, Fawcett JR, Rahman Y-E, Ala TA, Frey WH: Delivery of nerve growth factor to the brain via the olfactory pathway. J Alzheimer's Dis. 1998, 1: 35-44.

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