Author:
Zhou Chenhui,Huang Yi,Nie Sheng,Zhou Shengjun,Gao Xiang,Chen Gao
Abstract
AbstractFisetin, a natural flavonoid, possesses numerous biological activities that have been extensively studied in various diseases. When it comes to cancer, fisetin exhibits a range of biological effects, such as suppressing cell growth, triggering programmed cell death, reducing the formation of new blood vessels, protecting against oxidative stress, and inhibiting cell migration. Moreover, fisetin has the ability to enhance the effectiveness of chemotherapy. The anticancer properties of fisetin can be attributed to a diverse array of molecules and signaling pathways, including vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-κB), PI3K/Akt/mTOR, and Nrf2/HO-1. Consequently, fisetin holds promise as a therapeutic agent for anticancer treatment. In this review, we place emphasis on the biological functions and various molecular targets of fisetin in anticancer therapy.
Funder
The National Natural Science Foundation of China
The Medicine and Health Science and Technology Projects of Zhejiang Province
Ningbo Health Branding Subject Fund
Publisher
Springer Science and Business Media LLC
Cited by
7 articles.
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