Abstract
Abstract
Background
There are preliminary studies about the association between COVID-19 and ABO phenotypes and the results are controversial. There are only two studies which investigated the association of Rh blood groups in addition to ABO with COVID-19; however, in the statistical analysis ABO and Rh blood groups have been considered separately. Therefore, the present case-control study was performed to determine the association of COVID-19 with ABO blood groups considering the Rh blood groups simultaneously. The study was conducted in Kunduz COVID-19 treatment specific center, Spin-Zar Hospital (Kunduz Province, North East Afghanistan). A total of 301 confirmed COVID-19 cases and 1039 healthy blood donors as control group were included in the study.
Results
The Rh− phenotype strongly increased the risk of COVID-19 (OR = 2.97, 95% CI 1.86–3.89, P < 0.001). Although blood group A increased the risk of developing COVID-19, the association did not reach statistical significance. In analysis of the combination phenotypes, the A− blood group remarkably increased the risk of COVID-19 (OR = 7.24, 95% CI 3.62–14.4, P < 0.001). Multivariate analysis revealed that the interaction of Rh and ABO is significant (P < 0.013).
Conclusion
These findings indicate that susceptibility to COVID-19 is strongly associated with A− blood group.
Publisher
Springer Science and Business Media LLC
Reference36 articles.
1. Mousavi SH, Abdi M, Zahid SU, Wardak K (2020) Coronavirus disease 2019 (COVID-19) outbreak in Afghanistan: Measures and challenges. Infect Control Hosp Epidemiol. https://doi.org/10.1017/ice.2020.240
2. Brest P, Refae S, Mograbi B, Hofman P, Milano G (2020) Host polymorphisms may impact SARS-CoV-2 infectivity. Trends Genet 36:813–815
3. Di Maria E, Latini A, Borgiani P, Novelli G (2020) Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis. Hum Genomics 14:30
4. Saini S, Saini A, Thakur CJ, Kumar V, Gupta RD, Sharma JK (2020) Genome-wide computational prediction of miRNAs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) revealed target genes involved in pulmonary vasculature and antiviral innate immunity. Mol Biol Res Commun 9:83–91
5. Ansari-Lari M, Saadat M (2020) The morbidity and mortality of COVID-19 are associated with ABO and Rh blood groups. Eur J Prev Cardiol:2047487320939216. https://doi.org/10.1177/2047487320939216
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