Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice

Author:

Smith Byron J,Miller Richard A,Ericsson Aaron C,Harrison David C,Strong Randy,Schmidt Thomas MORCID

Funder

National Institute on Aging

Glenn Foundation for Medical Research

Burroughs Wellcome Fund

Publisher

Springer Science and Business Media LLC

Subject

Microbiology (medical),Microbiology

Reference75 articles.

1. Nadon NL, Strong R, Miller RA, Harrison DE. NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model. EBioMedicine. 2017; 21:3–4. https://doi.org/10.1016/j.ebiom.2016.11.038 .

2. Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, Nelson JF, Pletcher S, Simpkins JW, Smith DL, Wilkinson JE, Miller RA. Acarbose, 17- α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell. 2014; 13(2):273–82. https://doi.org/10.1111/acel.12170 .

3. Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE. Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell. 2016; 15(5):872–84. https://doi.org/10.1111/acel.12496 .

4. Harrison DE, Strong R, Alavez S, Astle CM, DiGiovanni J, Fernandez E, Flurkey K, Garratt M, Gelfond JAL, Javors MA, Levi M, Lithgow GJ, Macchiarini F, Nelson JF, Sukoff Rizzo SJ, Slaga TJ, Stearns T, Wilkinson JE, Miller RA. Acarbose improves health and lifespan in aging HET3 mice. Aging Cell. 2019; 18(2):12898. https://doi.org/10.1111/acel.12898 .

5. Laube H. Acarbose: An update of its therapeutic use in diabetes treatment. Clin Drug Inv. 2002; 22(3):141–56.

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