Wogonin inhibits in vitro herpes simplex virus type 1 and 2 infection by modulating cellular NF-κB and MAPK pathways

Author:

Chu Ying,Lv Xiaowen,Zhang Longfeng,Fu Xingli,Song Siwei,Su Airong,Chen Deyan,Xu Lianhong,Wang Yongfang,Wu Zhiwei,Yun Zhihua

Abstract

Abstract Background Wogonin, a natural flavonoid-like chemical compound, exhibits anti-inflammatory, antitumor, antiviral, neuroprotective, and anxiolytic effects by modulating a variety of cellular signaling pathways including PI3K-Akt, p53, nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK) pathways. In this study, its antiviral effect against herpes simplex virus (HSV) type 1 and 2 (HSV-1 and HSV-2) replication was investigated. Results Wogonin suppressed HSV-2-induced cytopathic effect (CPE) and reduced viral mRNA transcription, viral protein synthesis, and infectious virion particle titers in a dose-dependent manner. A time-of-drug-addition assay demonstrated that wogonin acted as a postentry viral inhibitor. Wogonin also significantly reduced HSV-induced NF-κB and MAPK pathway activation, which has previously been demonstrated to be important for viral replication. Conclusions Our results suggest that the anti-herpes effect of wogonin may be mediated by modulation of cellular NF-κB and JNK/p38 MAPK pathways and imply that wogonin may be useful as an anti-HSV agent.

Funder

Foundation of the Science and Technology Project of Wujin

Foundation of the Youth Science and Technology Project of Changzhou Health and Family Planning Commission

Innovative and Entrepreneurial Plan of Jiangsu Province

Changzhou High-Level Medical Talents Training Project

Special Fund for Clinical Medicine of Jiangsu University

Clinical Technology Development Foundation of Jiangsu University

Jiangsu Government Scholarship for Overseas Studies

Publisher

Springer Science and Business Media LLC

Subject

Microbiology (medical),Microbiology

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