Author:
Chu Ying,Lv Xiaowen,Zhang Longfeng,Fu Xingli,Song Siwei,Su Airong,Chen Deyan,Xu Lianhong,Wang Yongfang,Wu Zhiwei,Yun Zhihua
Abstract
Abstract
Background
Wogonin, a natural flavonoid-like chemical compound, exhibits anti-inflammatory, antitumor, antiviral, neuroprotective, and anxiolytic effects by modulating a variety of cellular signaling pathways including PI3K-Akt, p53, nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK) pathways. In this study, its antiviral effect against herpes simplex virus (HSV) type 1 and 2 (HSV-1 and HSV-2) replication was investigated.
Results
Wogonin suppressed HSV-2-induced cytopathic effect (CPE) and reduced viral mRNA transcription, viral protein synthesis, and infectious virion particle titers in a dose-dependent manner. A time-of-drug-addition assay demonstrated that wogonin acted as a postentry viral inhibitor. Wogonin also significantly reduced HSV-induced NF-κB and MAPK pathway activation, which has previously been demonstrated to be important for viral replication.
Conclusions
Our results suggest that the anti-herpes effect of wogonin may be mediated by modulation of cellular NF-κB and JNK/p38 MAPK pathways and imply that wogonin may be useful as an anti-HSV agent.
Funder
Foundation of the Science and Technology Project of Wujin
Foundation of the Youth Science and Technology Project of Changzhou Health and Family Planning Commission
Innovative and Entrepreneurial Plan of Jiangsu Province
Changzhou High-Level Medical Talents Training Project
Special Fund for Clinical Medicine of Jiangsu University
Clinical Technology Development Foundation of Jiangsu University
Jiangsu Government Scholarship for Overseas Studies
Publisher
Springer Science and Business Media LLC
Subject
Microbiology (medical),Microbiology
Cited by
29 articles.
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