Wogonin Inhibits Apoptosis and Necroptosis Induced by Nephropathogenic Infectious Bronchitis Virus in Chicken Renal Tubular Epithelial Cells

Author:

Qi Qiurong1,Li Ying1,Ding Mengbing1,Huang Cheng1,Omar Salma Mbarouk1,Shi Yan2,Liu Ping1ORCID,Cai Gaofeng1,Zheng Zhanhong1,Guo Xiaoquan1ORCID,Gao Xiaona1

Affiliation:

1. Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China

2. School of Computer and Information Engineering, Jiangxi Agricultural University, Nanchang 330045, China

Abstract

NIBV is an acute and highly contagious virus that has a major impact on the poultry industry. Wogonin, as a flavonoid drug, has antiviral effects, but there have been no reports indicating its role in renal injury caused by NIBV infection. The aim of this study is to investigate the antiviral effect of wogonin against NIBV. Renal tubular epithelial cells were isolated and cultured, and divided into four groups: Con, Con+Wog, NIBV and NIBV+Wog. We found that wogonin significantly inhibited the copy number of NIBV and significantly alleviated NIBV-induced cell apoptosis and necrosis. Moreover, wogonin inhibited the reduction in mitochondrial membrane potential and the aberrant opening of mPTP caused by NIBV. In conclusion, wogonin can protect renal tubular epithelial cells from damage by inhibiting the replication of NIBV and preventing mitochondrial apoptosis and necroptosis induced by NIBV.

Funder

National Natural Science Foundation of China

National Key R&D Program of China

Jiangxi Provincial Natural Science Foundation

Jiangxi poultry industry technology system

Jiangxi Province Graduate Student Innovation Special Fund Project

Publisher

MDPI AG

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