Author:
Pan Hongwei,Li Wei,Sun Enhua,Zhang Yi
Abstract
Abstract
Background
Bergeyella cardium infection is becoming increasingly prevalent in patients with infective endocarditis, suggesting its significance in disease pathogenesis. However, few studies have fully characterized this species.
Results
Herein, we report the morphological and physiological characteristics, as well as whole genome sequencing of a newly identified B. cardium HPQL strain isolated from a patient with infective endocarditis. Results from the cellular morphology and biochemical analysis provide basic knowledge on the new pathogen. The whole genome sequencing of B. cardium HPQL consists of a circular chromosome with a total length of 2,036,890 bp. No plasmid was detected. Comparative genomics were carried out then. Antibiotics resistance related genes, pathogenesis related genes, predicted insertion sequences, genome islands and predicted CRISPRs sequences were demonstrated. To our knowledge, this is the first study to provide a complete genome sequence for Bergeyella spp.
Conclusions
This study provides fundamental phenotypic and genomic information for the newly identified fastidious infective endocarditis causative bacteria, B. cardium. Our results provide insights into effective clinical diagnosis and treatment of this pathogen.
Funder
National Natural Science Foundation of China
the Key Research Foundation of Shandong Province, China
Key Technology Research and Development Program of Shandong
Natural Science Foundation of Shandong Province
Resident standardized training research of Qilu Hospital of Shandong University
Qilu Hospital Clinical Practical New Technology Fund
Publisher
Springer Science and Business Media LLC
Subject
Microbiology (medical),Microbiology
Cited by
2 articles.
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