The efficacy and safety of Danggui-Sayuk-Ga-Osuyu-Saenggang-tang on Korean patients with cold hypersensitivity in the hands: study protocol for a pilot, double-blind, randomized, placebo-controlled, parallel-group clinical trial

Author:

Ko Youme,Go Ho-Yeon,Cho Yoon-Young,Shin Ji-Hye,Kim Tae-Hoon,Choi Dong-Jun,Lee Jin-Moo,Jang Jun-Bok,Song Yun-Kyung,Ko Seong-Gyu,Sun Seung-Ho,Jeon Chan-Yong

Funder

Ministry of Health and Welfare

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Medicine (miscellaneous)

Reference22 articles.

1. Sun SH, Go HY, Ko SW, Cho YY, Shin JH, Kim TH, et al. A Delphi study for treatment standardization of coldness in hands and Feet. J Soc Preven Korean Med. 2015;19(3):131–40.

2. Bae KH, Lee JA, Park KH, Yoo JH, Lee Y, Lee S. Cold hypersensitivity in the hands and feet may be associated with functional dyspepsia: results of a multicenter survey study. Evid Based Complement Alternat Med. 2016;2016:8948690.

3. Hur YM, Chae JH, Chung KW, Kim JJ, Jeong HU, Kim JW, et al. Feeling of cold hands and feet is a highly heritable phenotype. Twin Res Hum Genet. 2012;15(2):166–9.

4. Lee SL, Lee KS, Song BK. The literature review on the cold hypersensitivity of women. Korean J Obstet Gynecol. 1996;9:55–80.

5. Herrick AL. Pathogenesis of Raynaud’s phenomenon. Rheumatology (Oxford). 2005;44(5):587–96.

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