Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer’s disease: randomized, double-blind, placebo-controlled study-Reference-Cited by-同舟云学术

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Pharmacodynamics of atabecestat (JNJ-54861911), an oral BACE1 inhibitor in patients with early Alzheimer’s disease: randomized, double-blind, placebo-controlled study

Published:2018-08-23 Issue:1 Volume:10 Page:
ISSN:1758-9193
Container-title:Alzheimer's Research & Therapy
language:en
Short-container-title:Alz Res Therapy

Author:

Timmers Maarten,Streffer Johannes Rolf,Russu Alberto,Tominaga Yushin,Shimizu Hiroko,Shiraishi Ayako,Tatikola Kanaka,Smekens Pascale,Börjesson-Hanson Anne,Andreasen Niels,Matias-Guiu Jorge,Baquero Miquel,Boada Mercè,Tesseur Ina,Tritsmans Luc,Van Nueten Luc,Engelborghs Sebastiaan

Funder

Janssen Research & Development, a division of Janssen Pharmaceutica N.V., Beerse, Belgium

Janssen Pharmaceutical K.K. Japan

Flanders Innovation & Entrepreneurship (VLAIO), Belgium

Publisher

Springer Science and Business Media LLC

Subject

Cognitive Neuroscience,Neurology (clinical),Neurology

Link

http://link.springer.com/content/pdf/10.1186/s13195-018-0415-6.pdf

Reference23 articles.

1. Citron M. Alzheimer’s disease: strategies for disease modification. Nat Rev Drug Discov. 2010;9:387–98.

2. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, et al. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7:280–92.

3. Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, et al. Beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 1999;286:735–41.

4. Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature. 1999;402:537–40.

5. Mulder SD, van der Flier WM, Verheijen JH, Mulder C, Scheltens P, Blankenstein MA, et al. BACE1 activity in cerebrospinal fluid and its relation to markers of AD pathology. J Alzheimers Dis. 2010;20:253–60.

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