Author:
Shi Lijun,Zhu Haiyun,Ma Jinhui,Shi Li-Li,Gao Fuqiang,Sun Wei
Abstract
Abstract
Objective
We aimed to evaluate the safety and efficacy of intra-articular (IA) magnesium (Mg) for postoperative pain relief after arthroscopic knee surgery.
Methods
We searched PubMed, Embase, Medline, Cochrane library, and Web of Science to identify randomized controlled trials that compared postoperative pain outcomes with or without IA Mg after knee arthroscopy. The primary outcomes were pain intensity at rest and with movement at different postoperative time points and cumulative opioid consumption within 24 h after surgery. Secondary outcomes included the time to first analgesic request and side effects.
Results
In total, 11 studies involving 677 participants met the eligibility criteria. Pain scores at rest and with movement 2, 4, 12, and 24 h after surgery were significantly lower, doses of supplementary opioid consumption were smaller, and the time to first analgesic requirement was longer in the IA Mg group compared with the control group. No significant difference was detected regarding adverse reactions between the groups.
Conclusions
Intra-articular magnesium is an effective and safe coadjuvant treatment for relieving postoperative pain intensity after arthroscopic knee surgery.
Protocol registration at PROSPERO: CRD42020156403.
Funder
Innovative Research Group Project of the National Natural Science Foundation of China
Biomedical Translational Engineering Research Center of BUCT-CJFH
Graduate Innovation Foundation of Peking Union Medical College
Publisher
Springer Science and Business Media LLC
Subject
Orthopedics and Sports Medicine,Surgery
Cited by
4 articles.
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