Affiliation:
1. Students Research Committee, Arak University of Medical Sciences, Arak, Iran
2. Department of Anesthesiology and Critical Care, Arak University of Medical Sciences, Arak, Iran
3. Department of Orthopedic, Arak University of Medical Sciences, Arak, Iran
Abstract
Abstract
Objectives:
The aim of this study was to compare the effects of intrathecal and intra-articular magnesium sulfate (IA-Mg) and fentanyl on pain after knee arthroscopy (KA).
Materials and Methods:
This double-blind clinical trial was conducted in 2022–2023. One hundred and forty candidates for KA were randomly allocated to four groups, namely intrathecal magnesium sulfate, IA-Mg, intrathecal fentanyl (IT-F), and intra-articular fentanyl. A medical intern used a 0–10 visual analog scale to assess participants’ post-KA pain at recovery and 1, 4, 6, 12, and 24 h after KA. Participants with a pain score of more than 4 were provided with intravenous pethidine 25 mg. Data were analyzed at a significance level of < 0.05 and using the SPSS software (version 22.0).
Results:
No significant difference was found among the groups respecting participants’ arterial oxygen saturation, heart rate, blood pressure, and KA duration (P > 0.05). The mean score of pain significantly increased in all study groups (P < 0.05) and the mean score of pain in the IA-Mg group was significantly less than the other groups (P = 0.001). Respecting postoperative complications, only six cases from the IT-F group experienced pruritus (P = 0.001).
Conclusion:
IA-Mg can significantly reduce post-KA pain and the need for postoperative analgesics. Therefore, it may be a safe and effective adjacent therapy for post-KA pain management.