Author:
Zhang Renjie,Zhang Yu,Liu Zheran,Pei Yiyan,He Yan,Yu Jiayi,You Chao,Ma Lu,Fang Fang
Abstract
Abstract
Objective
The prognosis of aneurysmal subarachnoid hemorrhage (aSAH) survivors is concerning. The goal of this study was to investigate and demonstrate the relationship between the neutrophil-to-albumin ratio (NAR) and long-term mortality of aSAH survivors.
Methods
A retrospective observational cohort study was conducted at Sichuan University West China Hospital between January 2009 and June 2019. The investigation of relationship between NAR and long-term mortality was conducted using univariable and multivariable Cox regression models. To demonstrate the predictive performance of different biomarkers over time, time-dependent receiver operating characteristic curve (ROC) analysis and decision curve analysis (DCA) were created.
Results
In total, 3173 aSAH patients were included in this study. There was a strong and continuous relationship between NAR levels and long-term mortality (HR 3.23 95% CI 2.75–3.79, p < 0.001). After adjustment, the result was still significant (adjusted HR 1.78 95% CI 1.49–2.12). Compared with patients with the lowest quartile (< 0.15) of NAR levels, the risk of long-term mortality in the other groups was higher (0.15–0.20: adjusted HR 1.30 95% CI 0.97–1.73; 0.20–0.28: adjusted HR 1.37 95% CI 1.03–1.82; >0.28: adjusted HR 1.74 95% CI 1.30–2.32). Results in survivors were found to be still robust. Moreover, out of all the inflammatory markers studied, NAR demonstrated the highest correlation with long-term mortality.
Conclusions
A high level of NAR was associated with increased long-term mortality among patients with aSAH. NAR was a promising inflammatory marker for long-term mortality of aSAH.
Funder
the 1·3·5 projects for disciplines of excellence-Clinical Research Incubation Project
the National Key R&D Program of China
the project of the health commission of Sichuan province
the project of the Sichuan Science and Technology Bureau
the Science and Technology Department Project of Sichuan Province
Clinical Incubation Program of West China Hospital, SCU
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Medicine
Cited by
2 articles.
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