Mediterranean dietary pattern and depression: the PREDIMED randomized trial

Author:

Sánchez-Villegas Almudena,Martínez-González Miguel Angel,Estruch Ramón,Salas-Salvadó Jordi,Corella Dolores,Covas Maria Isabel,Arós Fernando,Romaguera Dora,Gómez-Gracia Enrique,Lapetra José,Pintó Xavier,Martínez Jose Alfredo,Lamuela-Raventós Rosa María,Ros Emilio,Gea Alfredo,Wärnberg Julia,Serra-Majem Lluis

Abstract

Abstract Background A few observational studies have found an inverse association between adherence to a Mediterranean diet and the risk of depression. Randomized trials with an intervention based on this dietary pattern could provide the most definitive answer to the findings reported by observational studies. The aim of this study was to compare in a randomized trial the effects of two Mediterranean diets versus a low-fat diet on depression risk after at least 3 years of intervention. Methods This was a multicenter, randomized, primary prevention field trial of cardiovascular disease (Prevención con Dieta Mediterránea (PREDIMED Study)) based on community-dwelling men aged 55 to 80 years and women aged 60 to 80 years at high risk of cardiovascular disease (51% of them had type 2 diabetes; DM2) attending primary care centers affiliated with 11 Spanish teaching hospitals. Primary analyses were performed on an intention-to-treat basis. Cox regression models were used to assess the relationship between the nutritional intervention groups and the incidence of depression. Results We identified 224 new cases of depression during follow-up. There was an inverse association with depression for participants assigned to a Mediterranean diet supplemented with nuts (multivariate hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.55 to 1.10) compared with participants assigned to the control group, although this was not significant. However, when the analysis was restricted to participants with DM2, the magnitude of the effect of the intervention with the Mediterranean diet supplemented with nuts did reach statistical significance (multivariate HR = 0.59; 95% CI 0.36 to 0.98). Conclusions The result suggest that a Mediterranean diet supplemented with nuts could exert a beneficial effect on the risk of depression in patients with DM2. Trial registration This trial has been registered in the Current Controlled Trials with the number ISRCTN 35739639

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

Reference57 articles.

1. Mathers CD, Lopez AD, Murray CJL: The burden of disease and mortality by condition: data, methods, and results for 2001. Global Burden of Disease and Risk Factors. Edited by: Murray CJL, Jamison DT, Ezzati M, Mathers CD, Colin D, Lopez AD. 2006, Washington D.C: World Bank Publications, 45–240.

2. World Health Organization (WHO): The Global Burden of Disease 2004 Update. 2008, Geneva, Switzerland: World Health Organization

3. Sanchez-Villegas A, Martinez-Gonzalez MA: Diet, a new target to prevent depression?. BMC Med. 2013, 11: 3.

4. Sanhueza C, Ryan L, Foxcroft DR: Diet and the risk of unipolar depression in adults: systematic review of cohort studies. J Hum Nutr Diet. 2013, 26: 56-70.

5. Sánchez-Villegas A, Verberne L, De Irala J, Ruíz-Canela M, Toledo E, Serra-Majem L, Martínez-González MA: Dietary fat intake and the risk of depression: the SUN Project. PLoS One. 2011, 6: e16268.

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