Author:
Parodi Alessandro,Buzaeva Polina,Nigovora Daria,Baldin Alexey,Kostyushev Dmitry,Chulanov Vladimir,Savvateeva Lyudmila V.,Zamyatnin Andrey A.
Abstract
Abstract
Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications, including chemotherapeutics. In recent decades, the fields of material science and nanomedicine have generated several delivery platforms with high potential for overcoming multiple barriers associated to oral administration. This review describes the properties of several nanodelivery systems that improve the bioavailability of orally administered therapeutics, highlighting their advantages and disadvantages in generating successful anticancer oral nanomedicines.
Graphical Abstract
Funder
Russian Science Foundation
Publisher
Springer Science and Business Media LLC
Subject
Pharmaceutical Science,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,Medicine (miscellaneous),Bioengineering
Reference139 articles.
1. Administration UFaD. Novel drug approvals for 2018. 2018. https://www.fda.gov/drugs/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products/novel-drug-approvals-2018. Accessed 20 Apr 2021.
2. Schoener C, Peppas N. Oral delivery of chemotherapeutic agents: background and potential of drug delivery systems for colon delivery. J Drug Delivery Sci Technol. 2012;22(6):459–68.
3. Liu NF, Brown AS, Folias AE, Younge MF, Guzman SJ, Close KL, et al. Stigma in people with type 1 or type 2 diabetes. Clin Diabetes. 2017;35(1):27–34.
4. Weingart SN, Zhang L, Sweeney M, Hassett M. Chemotherapy medication errors. Lancet Oncol. 2018;19(4):e191–9.
5. Jacobs JM, Ream ME, Pensak N, Nisotel LE, Fishbein JN, MacDonald JJ, et al. Patient experiences with oral chemotherapy: adherence, symptoms, and quality of life. J Natl Compr Canc Netw. 2019;17(3):221–8.
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