Author:
Lu Chengli,Ma Zhiyuan,Cheng Xiaoming,Wu Huichao,Tuo Biguang,Liu Xuemei,Li Taolang
Abstract
AbstractBreast cancer is a common malignancy in women. Among breast cancer types, triple-negative breast cancer (TNBC) tends to affect younger women, is prone to axillary lymph node, lung, and bone metastases; and has a high recurrence rate. Due to a lack of classic biomarkers, the currently available treatments are surgery and chemotherapy; no targeted standard treatment options are available. Therefore, it is urgent to find a novel and effective therapeutic target. As alteration of ion channels and transporters in normal mammary cells may affect cell growth, resulting in the development and progression of TNBC, ion channels and transporters may be promising new therapeutic targets for TNBC. This review summarizes ion channels and transporters related to TNBC and may provide new tumor biomarkers and help in the development of novel targeted therapies.
Funder
National Natural Science Foundation of China
the Joint Funds of the Science and Technology Foundation of Guizhou Province
the 15851 Talent Projects of Zunyi City
the Outstanding Scientific Youth Fund of Guizhou Province
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Genetics,Oncology
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