Combinatorial Sec pathway analysis for improved heterologous protein secretion in Bacillus subtilis: identification of bottlenecks by systematic gene overexpression-Reference-Cited by-同舟云学术

Combinatorial Sec pathway analysis for improved heterologous protein secretion in Bacillus subtilis: identification of bottlenecks by systematic gene overexpression

Published:2015-06-26 Issue:1 Volume:14 Page:
ISSN:1475-2859
Container-title:Microbial Cell Factories
language:en
Short-container-title:Microb Cell Fact

Author:

Chen Jingqi,Fu Gang,Gai Yuanming,Zheng Ping,Zhang Dawei,Wen Jianping

Funder

State Key Development 973 Program for Basic Research of China

National Nature Science Foundation of China

the Key Projects in the Tianjin Science & Technology Pillar Program

Publisher

Springer Science and Business Media LLC

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://link.springer.com/content/pdf/10.1186/s12934-015-0282-9

Reference42 articles.

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2. Westers L, Westers H, Quax WJ (2004) Bacillus subtilis as cell factory for pharmaceutical proteins: a biotechnological approach to optimize the host organism. Biochim Biophys Acta 1694:299–310

3. Dong H, Zhang D (2014) Current development in genetic engineering strategies of Bacillus species. Microb Cell Fact 13:63

4. Phan TT, Nguyen HD, Schumann W (2012) Development of a strong intracellular expression system for Bacillus subtilis by optimizing promoter elements. J Biotechnol 157:167–172

5. Diao L, Dong Q, Xu Z, Yang S, Zhou J, Freudl R (2012) Functional implementation of the posttranslational SecB–SecA protein-targeting pathway in Bacillus subtilis. Appl Environ Microbiol 78:651–659

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